Criminal Profiling Real Science of Just Wishful Thinking...

Criminal profiling is an investigative technique used by many law enforcement agencies notably the Federal Bureau of Investigation (FBI) in the analysis of elusive criminals through studying their criminal profiles. Profiling is usually done on basis of the type and nature of crime. Usually studies are conducted as to the offenders whereabouts and occupation before, during and after a particular crime was committed. After this, evidence is then combined against the different types of personalities and a fitting description of the criminal is able to be formulated. However, it is important to note that in any criminal profiling attempt, the criminal psychological mind must be described fully by their actions during and after the crime. For†¦show more content†¦If asked the same question, I would perhaps reply by insinuating that while it may actually be luck profiling really helps in the narrowing down of the list of possible offenders and thus in my opinion it is quite effec tive. The purpose of this paper is thus to analyze in detail, whether or not criminal profiling is beneficial or is it just real science of wishful thinking? How effective is Criminal Profiling in the Solving of Crimes? Many critics of criminal profiling presume that criminal profiles are usually too big to create the desired picture and that it takes a little more than common sense to successfully profile a criminal. If we are to acknowledge that profiling is a science, then it is only so because psychology as a science comes into focus in the solving of crimes. It is and has been proven possible, that the psychological study of people helps in the determination of their behavioral dispositions accurately. Going from this statement, it is thus of importance to realize the fact that criminal profiling is a major asset to many law enforcement agencies as some crimes are just not ordinary, and require specific studies into their nature for a proper profile to be acquired. It should be noted that normal police investigations depend largely on the criminal’s motif. So what happens if there is no motifShow MoreRelatedCrimnal Profiling, Science or Not?1847 Words   |  8 Pagesin â€Å"Criminal Profiling: Science or Not† Jennifer Dean Forensic Psychology Tcherni November 2012 The FBI officially began criminal profiling in 1970; the profiling program was introduced by Howard Teton. However, this is not where criminal profiling began. The first verified introductions to profiling were demonization of the Jews, witches and puritans; some dating back to 1144. (Turvey 2011) Criminal profiling is the tool of investigation used by skilled law enforcement professionals

Definitions of War of the Worlds Essay Topics

Definitions of War of the Worlds Essay Topics Second is to learn your reader in order to have the thought of the topic you're likely to write. The well-known D-Day landing happened on June 6, 1944 stating the beginning of the operation Overlord. It was very dangerous to leave the trench because if any movement was seen on both sides, he command was supposed to shoot. The most important problem happens when a student is assigned with a topic together with a word length. If you'd like to create a similar speech, you may also incorporate a list of toxic substances and provide the details on how they affect the surroundings. Fill in the purchase form and you'll get your special interview essay in no moment! The admission officer is a wise person. Only time might have allowed him to find that info. New Questions About War of the Worlds Essay Topics In some instances, the college will give an essay topic for you. To compose a strong argumentative essay, students should start b y familiarizing themselves with a number of the common, and frequently conflicting, positions on the research topic so they can write an educated paper. Analysis essays are known to be among the hardest to write. Students will have to do research so as to compose full essays for each topic. The 30-Second Trick for War of the Worlds Essay Topics The rumor was checked and shown to be inaccurate. The researched material needs to be read carefully as a way to take out the notes. Don't forget to read the directions carefully since there are often clues in the questions. In the writing it's crucial that you answer the question and don't attempt to modify the question at all. Writing a humorous essay is just one of the most effective ways to continue to keep your readers engrossed. To begin with, your motivation for a writer is affected by the essay topic you select. To develop a fantastic bit of writing, one needs to be craft a very good introduction since it is the very first thing a reader reads after the subject of the war essay. Don't forget that each and every statement you make in your essay has to be proved. In case the interview went well, it is going to be simple to compose an interview essay. Pay attention to the proper spelling when you proofread your essay. An analysis essay is a type of persuasive essay. Hearsay, Lies and War of the Worlds Essay Topics Politics is another crucial contributor to the start of war and conflict. The USA came from the war significantly strengthened. For instance, the Hitler's army was able to conquer one of the strongest states in Europe, France. Another important political broadcast focused on the problem of Czechoslovakia. The show made headlines in virtually every significant American news publication. It proved to individuals all around the globe that given the right circumstances media can create and shape public perceptions. The political effect on literature cannot be ignored. Have a focus on what you're doing and always don't forget that you are abl e to bring out the finest in you. At exactly the same time, detecting cause and effect relationships isn't that easy in regards to the selection of an excellent cause and effect essay topic. It is essential that you expand your answers and demonstrate a wide selection of grammatical structures and vocabulary. The Nuiances of War of the Worlds Essay Topics Discuss methods by which war is beneficial to a society. Last words of advice here is that you also have to read about the other religions in order to find a better mastery of the term religion. The third source of world war II was the growth of Fascism. The last cause of world war II was an immediate result from each one of the prior causes, and that's the rearmament of all of the European powers. The Debate Over War of the Worlds Essay Topics The college essay is among the most significant facets of your college application. One of the greatest ways we've found to help is by giving a selection of college essay examples. One of the most important skills that has to be proven is one's capacity to simply compose a college essay. If you are in possession of a wonderful topic for your next writing task, you will come to find it simpler to begin your writing with creative and associated ideas that keep on flowing. The One Thing to Do for War of the Worlds Essay Topics Fear A significant facet of The War of the Worlds is the notion of fear. In truth, it is an amazing trait which should be cultivated by everyone. There isn't any doubt that terrorism has a profound influence on the world. The narrator is trying to survive and does not have any idea if he will or how.

Oxidative Stress and Diabetic Nephropathy Free Essays

Introduction Diabetes mellitus is a chronic non-communicable condition resulting in high levels of glucose in the blood. It occurs due to inability of the beta cells in pancreas islet tissue to produce enough insulin, or when the body becomes resistant to insulin. It reduces both quality and length of life and over time leads to serious complications such as coronary heart disease, stroke, neuropathy, retinopathy and nephropathy. We will write a custom essay sample on Oxidative Stress and Diabetic Nephropathy or any similar topic only for you Order Now There are two main types of diabetes mellitus: Type 1 diabetes: also called insulin-dependent diabetes mellitus (IDDM), early-onset and juvenile diabetes. It is an autoimmune disease and results from destruction of insulin producing beta cells in islet tissues of pancreas by the body’s immune system. The subsequent lack of insulin results in high blood glucose levels, which if not controlled by exogenous insulin results in multiple organ damage. Type 2 diabetes: formerly called non-insulin-dependent (NIDDM) and adult-onset. It is a metabolic disorder that mainly occurs in individuals over the age of 40. In this type of diabetes high blood glucose results either due to relative insulin deficiency or insulin resistance. Lifestyle and genetic factors play an important role in the development of type 2 diabetes. Type 2 diabetes is a growing problem among the elderly population and is widely predicted to grow in the future. Since the population is aging in the western world, so it is not surprising that elderly population will contribute to future increase but other factors such as lifestyle and diet will also play a major role. WHO survey 2010 estimated that 285 million of the world’s population have diabetes and more than 70% of them live in low and middle income countries. It is also estimated that this burden will increase to 438 million by 2030 (Diabetes fact, 2011). Wild 2004 projected that the total number of individuals with diabetes worldwide will increase from 171 million in 2000 to 366 million 2030. Although the prevalence of diabetes is higher in men compared to women but there are more women with diabetes than men. In developing countries type 2 diabetes mainly affects people of working age, between 35 and 64 years, whereas in developed countries the majority of people with diabetes are above the age of retirement i.e. above 65 years of age (WDD06 – Karachi, 2006). India has the largest diabetes world’s population i.e. 50.8 million followed by China with 43.2 million ( Express news report, 2009). In Europe prevalence of clinically diagnosed diabetes was estimated to be 3% in 1997. It was estimated to increase to around 3.6% by 2000 and to over 4% by 2010 (Scottish Diabetes Survey 2003). In UK 4.26 % of population has diabetes according to the Diabetes UK statistics (Diabetes prevalence 2010). Scottish Diabetic Survey, 2010, projects that 4.6% of Scotland population has diabetes out of which 87.7% have type 2 diabetes. Diabetes is also at an increase among children. Diabetes amongst children is primarily Type 1 diabetes but Type 2 diabetes is also increasingly being diagnosed. One of the major contributing factors for this rise in diabetes among children is the increase in the number of children who are overweight or obese. â€Å"Twenty five children in every 100,000 in Scotland have diabetes, compared to 17 in England and Wales.† An increase in this at a rate of 2% per years has been suggested by Diabetes UK in Scotland, as a result tripling of new cases in the last 30 years has been seen (ABPI Report Scotland, 2005). Economic burden of Diabetes for families and society: Diabetes and its complications have a significant economic impact on individuals, families, health systems and countries. For example, WHO estimates that in the period 2006-2015, China will need to allocate $558 billion in foregone national income due to heart disease, stroke and diabetes alone and India will spend $336.6 billion (Diabetes, 2011). â€Å"In the poorest countries, people with diabetes and their families bear almost the whole cost of the medical care they can afford.† In Latin America, 40-60% of medical care expenditures is paid by the families themselves. In Mozambique, 75% of the per capita income is spent on diabetic care by one person; in Mali it amounts to 61%; Vietnam is 51% and Zambia 21%. It is estimated that poor people with diabetes in some developing countries spend as much as 25% of their annual income on private care (Diabetes fact. April 2011). The trend of diabetes in developing countries show that it mostly affects working age group, between 35 and 64 years, relative to developed countries where the majority of diabetes population are aging. Therefore when principal wage earner is affected by diabetes and its complications, the choice between healthcare expenses and food or clothing can trap the whole family in a downward spiral of worsening poverty and health. According to WHO, an annual 2% reduction in chronic disease death rates in Pakistan would provide an economic gain of 1 billion dollars over the next 10 years (WDD06 – Karachi, 2006). The cost incurred by diabetes morbidity are far greater than the cost of the disease prevention (Editorial in Lancet: World Diabetes Day 14th November, 2010). In a press report by the independent economic consultancy group NERA it is assessed that intensive management of Type 2 diabetes in Scotland can decrease hospital cost by ?41 million by saving over 91,000 bed days a year in 2025 and will also save ?78 million a year in lost work days (ABPI Report Scotland, 2005). Diabetic Nephropathy: The diabetic complication, nephropathy is a condition with high unmet therapeutic needs. It is linked with significant increases in morbidity and mortality risk, and is the most common cause of ESRD in the Western countries. Diabetes-induced damage in the kidney leads to microalbuminuria. This progresses to ESRD, which requires dialysis or transplantation. Diabetes accounts for over 40% of ESRD (Diabetic Nephropathy, 2003). The main focus of therapy in diabetic nephropathy is on tight control of blood pressure. Guidelines have progressively revised the target BP goal downwards, currently at 125/75 mmHg in patients with 1g proteinuria, and now recommend either ACE or ARB (Diabetic Nephropathy, 2003). In the U.S., diabetic nephropathy accounts for about 40% of new cases of ESRD. In 1997 the cost required for treatment of diabetic patients having ESRD amounts to $15.6 billion. There is considerable racial/ethnic variability in this regard, Native Americans, Hispanics (especially Mexican-Americans), and African-Americans have much higher risks of developing ESRD than non-Hispanic whites with type 2 diabetes (Mark, 2001). In the UK, 1,000 people with diabetes start kidney dialysis every year. (Diabetes in the UK, 2004). Ahmedani 2005 reports that in Karachi, Pakistan overall prevalence of microalbuminuria was found to be 34% in patients with diabetes and this was strongly associated with the age, diastolic hypertension, diabetic retinopathy and serum low density lipoprotein. End stage renal disease is a most serious complication of diabetes and accounts to be the most expensive for NHS. Diabetic nephropathy usually develops 15-25 years after the occurrence of diabetes. In Scotland, 20% of patients who undergo renal transplantation are diabetic. In diabetic individuals, microalbuminuria and stroke, or an increased serum creatinine levels raises the risk of renal nephropathy and failure. Poor glycemic control and high blood pressure are risk factors of diabetic renal disease (Scottish Diabetes Framework, 2002). Diabetic renal impairment is a strong indicator of Cardiovascular disease and cardiovascular disease is the major cause of morbidity and mortality is diabetic patients (Guillausseau, 2011). Annual cardiovascular mortality is 0.7% in normoalbuminuric patient as compared to 2% in microalbuminuric patients and 12% in the patient with elevated creatinine (Stratton IM, 2009) In a review by Vishwanathan, 1999, it is explained that South Asians and Afro-Caribbean are more susceptible to develop renal disease relative to European. Retinopathy increases the risk of diabetic nephropathy. Prevalence of diabetic nephropathy in India was 30.3% in a study done among 4837 patients with chronic renal failure over a period of 10 years. He further argued that an increased prevalence of microalbuminurea among South Asians having type 2 diabetes mellitus relative to Europeans by 1.2 (men) and 1.7 (women) folds. According to SIGN 116, the incidence of diabetic nephropathy in patient with type 1 diabetes can be considerably reduced by attaining good glycaemic and tight blood pressure control.  ­ In a report by Singh NP, 2003, it is suggested that the incidence of diabetic kidney disease can be reduced by: tight blood glucose control, blood pressure control, rennin-angiotensin-aldosterone system blockade and protein restriction. Causes of microvascular damage in diabetes: Long standing hyperglycemia lead to a number of damages including: Advanced glycosylated end products (AGES) Oxidative stress Increased sorbitol (polyol pathway) Increase in hexosamine pathway Impaired endothelial function Immune effect All these damages result in microvascular complications of diabetes. Advanced glycosylated end-products (AGEs): Chronic hyperglycemia causes increased glycosylation of proteins leading to AGEs, which in turn results in loss of structure and function, turning on/off signal pathways within cells and alteration in gene expression. AGEs are sugar-derived compounds, glucose binds amino groups on proteins, lipids and nucleic acids to form AGEs. AGEs form at a constant but slow rate throughout your life (even as an embryo) (Peppa et al, 2003). AGEs interact with RAGE (surface AGE-binding receptors) resulting in proinflammatory effects, formation reactive oxygen species, loss of oxidants (oxidative stress) and altered gene transcription. Levels of AGEs relates to extent of microvascular complications in diabetes. AGEs contributes to atheromatous plaque by stimulating low-density lipoprotein (LDL) oxidation and the deposition of oxidized LDL. AGEs leads to endothelial dysfunction, macrophage activation, and impaired vascular smooth muscle cell function. Experimentally, AGEs cause glomerular damage and proteinuria. Oxidative stress and Reactive Oxygen Species (ROS): Oxidative stress is an imbalance between ROS production and antioxidants. Oxygen is used by cells to carry out their normal functions and as a side effect produces free radicals. Free radicals are missing an electron so are unstable and highly reactive. Free radicals steal electrons from molecules within cells causing oxidative damage to proteins, membranes and genes. Polyol pathway/aldose reductase: Aldose reductase (AR) normally reduces toxic aldehydes into inactive alcohols inside the cells. Glucose perfuses into some cells without insulin e.g. nerves. During hyperglycaemic condition, AR reduces that excess glucose to sorbitol (a polyol). Polyols are trapped inside the cells creating an osmotic gradient. Sodium and water flow into the cell resulting in oedema. But sorbitol can be metabolised to fructose by the actions of sorbitol dehydrogenase. High fructose leads to AGEs resulting in more cell damage (Takaqi et al, 1995). Hexosamine pathway: Glucose is mainly metabolised through glycolysis, some gets diverted into an alternative pathway, ending up as UDP (urine diphosphate) N-acetyl glucosamine. This alters transcription factors, often leading to pathologic changes in gene expression e.g. increased expression of transforming growth factor-B1 and plaminogen activator inhibitor-1, which damages blood vessels. Endothelial dysfunction – pathogenesis: Hyperglycemia leading to the formation of AGEs, ROS, the glycosylation of proteins and increased inflammatory cytokines etc. As a result small blood vessels, particularly the endothelium are damaged causing vasoconstriction, ischemia, and reduced flow to tissues that rely on the vessel for oxygen and nutrients. Growth factors are also released leading to the blood vessel wall thickening and occlusion of small blood vessels. Nerve growth factors (NGF) and factors like it are damaged. These factors keep nerves healthy and capable of re-growth if damaged. Changes to the immune system lead to release of toxic cytokines, blockage of blood vessels with leukocytes and loss of normal immune cell action. In this dissertation, a recent aspect of one of the above causes of microvascular damage of diabetes leading to nephropathy will be considered. Current studies have uncovered new insights in the role of oxidative stress in diabetic renal disease, suggesting a different and innovative approach to a possible â€Å"casual† antioxidant therapy. In this dissertation the role oxidative stress may play in the development of diabetic kidney disease will be discussed. The role of antioxidant therapy in managing or delaying the progression of diabetic nephropathy will be addressed. REFERENCES: Ahmedani M Y, (2005) Prevalence of Microalbuminuria in Type 2 Diabetic Patients in Karachi: Pakistan A Multi-center Study: http://www.jpma.org.pk/full_article_text.php?article_id=856 ABPI Report Scotland, (2005)The future burden of CHD and Diabetes in Scotland: The value of health care innovation. Available at: s3.amazonaws.com/zanran_storage/www.abpi.org.uk/†¦/50031328.pdf Diabetes fact. (2011) Available at: http://www.worlddiabetesfoundation.org/composite-35.htm Diabetes (2011), Available at: http://www.who.int/mediacentre/factsheets/fs312/en/ Diabetic Nephropathy 2003. Available at: http://www.datamonitor.com/Products/Free/Brief/BFHC0625/010BFHC0625.pdf Express news report, India has largest number of diabetes patients: Report (2009) http://www.indianexpress.com/news/india-has-largest-number-of-diabetes-patient/531240/ Diabetes in the UK 2004, www.diabetes.org.uk/Documents/Reports/in_the_UK_2004.doc Guillausseau, (2011) Type 2 diabetes and cardiovascular risk: kidney function is pivota. Available at: http://www.diafocus.com/2011/01/11/type-2-diabetes-and-cardiovascular-risk-kidney-function-is-pivotal/ Peppa M, Uribarri J, Vlassara H, 2003, Glucose, Advanced Glycation End Products, and Diabetes Complications: What is New and What Works. Available at: http://clinical.diabetesjournals.org/content/21/4/186.full Stratton IM, (2009) Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study Available at: http://articulos.sld.cu/medicinainterna/files/2009/10/association-of-glycaemia-with-macrovascular-and-microvascular.pdf Scottish Diabetes Framework. (2002) Available at: http://www.scotland.gov.uk/Publications/2002/04/14452/1986 Scottish Diabetes Survey 2003, Available at: http://www.scotland.gov.uk/Publications/2004/10/20023/44203 Singh NP, Singh D, 2003, Diabetes Mellitus – An Overview For Family Physicians. Available at: http://delhimedicalcouncil.nic.in/diabetes-mellitus.html Sign 116, Available at: http://www.sign.ac.uk/pdf/sign116.pdf Scottish Diabetes Survey 2010, Available at: http://www.diabetesinscotland.org.uk/Publications/Scottish%20Diabetes%20Survey%202010.pdf Takaqi Y, Kashiwaqi A, Tanaka Y, Asahina T, Kikkawa R, Shigeta Y, 1995, Significance of fructose-induced protein oxidation and formation of advanced glycation end product. Available at: http://www.ncbi.nlm.nih.gov/pubmed/7599353 Viswanathan V, (1999) Type 2 diabetes and diabetic nephropathy in India—magnitude of the problem. Available at: http://ndt.oxfordjournals.org/content/14/12/2805.full WILD S et al, (2004) Global Prevalence of Diabetes. Available at: http://www.who.int/diabetes/facts/en/diabcare0504.pdf WDD06 – Karachi, (2006). Diabetes kills without distinction. Available at: http://www.idf.org/wdd06-karachi How to cite Oxidative Stress and Diabetic Nephropathy, Essay examples